Related Experiment Video
Updated: Jun 4, 2025

05:38
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
24
Lupus erythematosus and dermatomyositis
Sarika Ramachandran1, Alicia J Little1, Jeff R Gehlhausen1
1Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA.
Clinics in Dermatology
|December 18, 2024
Summary
Dr Irwin M. Braverman pioneered understanding skin signs of systemic disease, linking internal medicine and dermatology. His work on lupus erythematosus and dermatomyositis remains crucial for diagnosing systemic conditions through skin examination.
Area of Science:
- Dermatology
- Internal Medicine
- Systemic Diseases
Background:
- Dr Irwin M. Braverman integrated internal medicine and dermatology.
- His book, "Skin Signs of Systemic Disease," became a foundational text for dermatologists globally.
- He focused on the cutaneous manifestations of systemic illnesses.
Purpose of the Study:
- To honor Dr Braverman's contributions to dermatology and internal medicine.
- To highlight his pioneering work in clinicopathologic correlation.
- To emphasize the significance of his research on autoimmune connective tissue diseases, specifically lupus erythematosus and dermatomyositis.
Main Methods:
- Review of Dr Braverman's seminal work and contributions.
- Analysis of his observations on the cutaneous manifestations of systemic diseases.
- Focus on his documentation of clinical signs and symptoms in lupus erythematosus and dermatomyositis.
Main Results:
- Dr Braverman's meticulous documentation established a standard for dermatologic training.
- His work provided critical insights into the clinical presentation of systemic lupus erythematosus and dermatomyositis.
- His legacy emphasizes the importance of connecting skin pathology to systemic disease.
Conclusions:
- Dr Braverman's legacy as a trailblazer in clinicopathologic correlation continues to influence dermatologists.
- His emphasis on the skin as an indicator of systemic pathology remains vital for patient care.
- His contributions significantly advanced the understanding of autoimmune connective tissue diseases through dermatologic examination.
Related Concept Videos
Skin Diseases and Disorders
2.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.9K
Autoimmune Disorders
385
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
385
T Cell Types and Functions
947
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
947
Myasthenia Gravis: Overview and Treatment
1.2K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.2K
Disorders of the Skeletal Muscle
871
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
871
Skin Cancer
3.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.1K

