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Updated: Jun 4, 2025

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting
Baocai Liu1, Yadong Zhang1, Quan Wang1
1Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Abstract:
CD40, a member of the tumor necrosis factor (TNF) receptor superfamily, plays an important role not only in the immune system but also in tumor progression. CD40 ligation reportedly promotes autophagy in immune cells. However, the effects of CD40 ligation on autophagy and its mechanism in solid tumor cells are still unclear. In this study, we find that CD40 ligation promotes autophagosome formation and consequently promotes autophagic flux in cervical cancer cells. Mechanistically, this effect relies on ERK contributing to CD40 ligation-induced ATG13 upregulation by p53. Furthermore, we demonstrate that CD40 ligation-induced autophagy increases the radiosensitivity of cervical cancer cells. Taken together, our results provide new evidence for the involvement of the CD40 pathway in autophagy and radiotherapy in cervical cancer cells.
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