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Related Concept Videos

Drug Concentrations: Measurements01:23

Drug Concentrations: Measurements

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Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
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Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Related Experiment Video

Updated: Jun 4, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
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The Monitoring Illicit Substance Use Consortium: A Study Protocol.

Christopher J Greenwood1,2,3, Primrose Letcher1,2,3, Esther Laurance1

  • 1Deakin University, Geelong, Australia.

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|December 19, 2024
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Summary

The Monitoring Illicit Substance Use (MISUse) Consortium combines four Australian and New Zealand cohort studies to investigate illicit drug use. This collaboration aims to understand substance use patterns and inform public health interventions.

Keywords:
cross-cohortillicit substance useprospective

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Area of Science:

  • Public Health
  • Epidemiology
  • Adolescent Health

Background:

  • Global illicit substance use poses a significant disease burden, particularly in Australia and New Zealand.
  • Adolescence and young adulthood are critical periods for the acceleration of substance use and associated harms.
  • Low prevalence of individual substance classes hinders detailed study in single cohort research.

Purpose of the Study:

  • To establish a consortium of mature prospective cohort studies to overcome limitations in studying illicit substance use.
  • To enable well-powered research into the natural history and consequences of illicit substance use.
  • To identify modifiable determinants of substance use for targeted policy and intervention.

Main Methods:

  • The Monitoring Illicit Substance Use (MISUse) Consortium was formed by integrating four established cohort studies.
  • Participating studies include the Christchurch Health and Development Study, Australian Temperant Project, Victorian Adolescent Health Cohort Study, and International Youth Development Study.
  • Data collection spans multiple waves from 1977 to the present, involving thousands of participants.

Main Results:

  • The consortium facilitates robust analysis of illicit substance use due to pooled sample sizes.
  • This enables detailed investigation into developmental antecedents and long-term outcomes of substance use.
  • The combined data allows for identification of key factors influencing substance use behaviors.

Conclusions:

  • The MISUse Consortium provides a powerful resource for understanding illicit substance use.
  • Findings can inform evidence-based public health policies and interventions.
  • This collaborative approach strengthens research capacity in adolescent substance use and its impacts.