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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

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Published on: October 6, 2018

Ethical frontiers in liver transplantation.

Hoi Pong Nicholas Wong¹, Surya Varma Selvakumar¹, Pei Yi Loh¹

¹Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.

World Journal of Transplantation

|December 19, 2024

Summary

Liver transplantation offers hope for end-stage liver disease patients, but ethical challenges in organ donation, allocation, and new technologies require careful navigation to ensure equitable access and societal well-being.

Keywords:

Ethics Gene editing Liver transplant Organ donation Transplant tourism Xenotransplantation

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Area of Science:

Medical Ethics
Transplantation Surgery
Bioethics

Background:

Liver transplantation is a critical treatment for end-stage liver disease.
Significant advancements in surgical techniques and organ procurement exist.
Ethical dilemmas persist, necessitating careful consideration of transplant protocols.

Purpose of the Study:

To explore modern ethical challenges in liver transplantation.
To analyze ethical principles of justice, autonomy, and beneficence in transplant protocols.
To investigate ethical dimensions of organ allocation, emerging technologies, and decision-making.

Main Methods:

Comprehensive literature search of PubMed, Scopus, Web of Science, Embase, and Central databases up to February 29, 2024.
Keywords included "liver transplant", "transplantation", "liver donation", "liver recipient", "organ donation", and "ethics".
Extraction of information on ethical discussions concerning recipients, allocation, donation, transplant tourism, and new technologies.

Main Results:

Ethical quandaries span from defining death to long-term recipient follow-up.
Societal perceptions, cultural, religious, and regional factors significantly influence attitudes towards donation and new technologies.
Addressing diverse perspectives while upholding bioethical principles is crucial for resource allocation.

Conclusions:

Liver transplantation significantly improves quality of life for end-stage liver disease patients.
Ethical considerations in transplantation are multifaceted, involving donors, recipients, and society.
Robust oversight, equitable access, and prioritization of genuine needs are essential for ethical liver transplantation.