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Updated: Apr 28, 2026
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Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord
Published on: May 23, 2021
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Research progress in in vivo tracing technology for extracellular vesicles.
Yanhua Shi1,2,3,4, Xianghui Wang1,5,4, Shifang Zhang6
1School of Bioscience and Technology, Weifang Medical University, Weifang 261053, Shandong, China.
Extracellular Vesicles and Circulating Nucleic Acids
|December 19, 2024
Summary
Extracellular vesicles (EVs) are crucial for cell communication and are being explored for therapies. This review covers molecular imaging techniques for tracking EVs within living organisms to understand their biological roles.
Area of Science:
- Biomedical Sciences
- Cell Biology
- Molecular Imaging
Background:
- Cells release extracellular vesicles (EVs) containing proteins and nucleic acids, mediating cell-cell communication.
- EVs are involved in numerous physiological and pathological processes.
- Understanding EV function is vital for developing EV-based therapies.
Purpose of the Study:
- To review typical applications of *in vivo* extracellular vesicle tracing.
- To discuss the role of molecular imaging in tracking EVs within living organisms.
Main Methods:
- Molecular imaging techniques including bioluminescence, fluorescence, MRI, SPECT, PET, photoacoustic, and multimodal imaging were employed.
- Each technique offers distinct advantages and disadvantages for *in vivo* EV tracing.
Main Results:
- *In vivo* tracing of EVs is essential for understanding EV-based therapy mechanisms.
- Molecular imaging technologies enable the visualization and tracking of EVs in real-time within organisms.
Conclusions:
- Molecular imaging is a powerful tool for *in vivo* extracellular vesicle research.
- Further research into EV tracing applications can advance therapeutic strategies.
