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Updated: Jun 4, 2025

Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species
Published on: May 7, 2018
Evolutionary conservation analysis of human sphingomyelin metabolism pathway genes
Siyuan Wang1, Huan Jiang1, Moran Hu1
1Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China.
Abstract:
Sphingomyelin is an important member of the sphingolipid family and was first reported more than a century ago. It has been demonstrated that sphingomyelin plays a crucial role in compositing cell membranes and signaling pathways. Despite extensive functional studies on the sphingolipid metabolism pathway genes, one intriguing question remains: how does the emergence of these genes during evolution correlate with the acquisition of new functions in different species? By employing an evolutionary conservation analysis, the sequence of occurrence of biological processes during evolutionary history can be elucidated. Here we summarize and analyze the conservation status of the genes involved in sphingomyelin metabolism.
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