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The Influence of Cancer Type on Stroke Incidence: A Retrospective Study
İbrahim Acır1, Hacı Ali Erdoğan1, Ertuğrul Toka1
1Neurology Department, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.
Clinical Medicine Insights. Oncology
|December 19, 2024
Summary
Cancer-related stroke patients show varied hematological and biochemical markers depending on cancer type. Elevated markers like d-dimer in pancreatic and rectal cancers suggest hypercoagulability and increased stroke risk.
Area of Science:
- Neurology
- Oncology
- Hematology
Background:
- Cancer patients face an elevated risk of stroke.
- Understanding the specific hematological and biochemical profiles associated with cancer-related stroke is crucial for risk stratification and management.
Purpose of the Study:
- To investigate hematological and biochemical variables in patients with cancer-related stroke.
- To evaluate how different cancer types influence these variables and their impact on stroke.
Main Methods:
- Retrospective study of 153 cancer-related stroke patients.
- Classification of stroke etiology using the Trial of Org 101072 in Acute Stroke Treatment (TOAST) criteria.
- Analysis of laboratory parameters including d-dimer, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fibrinogen.
Main Results:
- Significant variations in glomerular filtration rate, activated partial thromboplastin time, prothrombin time, and international normalized ratio were observed across different cancer types (P < 0.05).
- Elevated d-dimer, CRP, and ESR levels were noted in specific cancers like rectal, endometrial, and pancreatic cancers (P < 0.01).
- These findings indicate a strong link between hypercoagulability and stroke risk in certain cancer patients.
Conclusions:
- Cancer type significantly influences hematological and biochemical profiles in stroke patients.
- Pancreatic and colon cancers are associated with an earlier stroke occurrence.
- Elevated coagulation factors suggest a potential need for early anticoagulant or thrombin inhibitor therapy.
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