Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

One-pot synthesis of interfacially bonded Bi<sub>4</sub>O<sub>5</sub>Br<sub>2</sub>/Bi<sub>2</sub>S<sub>3</sub> Z-scheme heterostructures with boosted photocatalysis towards dodecylbenzenesulfonate and real hotel laundry wastewater.

Chemosphere·2024

Same author

Long-non-coding RNA AK001058: A genetic biomarker in cisplatin sensitivity of non-small-cell lung carcinoma.

Cellular and molecular biology (Noisy-le-Grand, France)·2024

Same author

Nano-Drug Delivery Systems in Oral Cancer Therapy: Recent Developments and Prospective.

Pharmaceutics·2024

Same author

Quantitative Determination of Poly(methyl Methacrylate) Micro/Nanoplastics by Cooling-Assisted Solid-Phase Microextraction Coupled to Gas Chromatography-Mass Spectrometry: Theoretical and Experimental Insights.

Analytical chemistry·2024

Same author

Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription.

Journal of bioenergetics and biomembranes·2024

Same author

Preparation of highly dispersed Ni single-atom doped ultrathin g-C<sub>3</sub>N<sub>4</sub> nanosheets by metal vapor exfoliation for efficient photocatalytic CO<sub>2</sub> reduction.

Journal of colloid and interface science·2024

Same journal

Radiation induces an EGFR-dependent lactate-epigenetic program underlying synergy with EGFR inhibition.

Cellular oncology (Dordrecht, Netherlands)·2026

Same journal

Neural regulation of cancer: from synaptic integration to neuro-immune regulation.

Cellular oncology (Dordrecht, Netherlands)·2026

Same journal

Enriched environment inhibits melanoma by reshaping gut microbiota and enriching Parabacteroides distasonis.

Cellular oncology (Dordrecht, Netherlands)·2026

Same journal

Molecular classification identifies aggressive gastrointestinal stromal tumor subtype targetable by PARP inhibitors.

Cellular oncology (Dordrecht, Netherlands)·2026

Same journal

Acinar-ductal metaplasia in pancreatitis and pancreatic ductal adenocarcinoma.

Cellular oncology (Dordrecht, Netherlands)·2026

Same journal

RRM1 competes with NEDD4 to stabilize USP19 by blocking K387 ubiquitination and suppresses autophagy-mediated chemoresistance in colorectal cancer.

Cellular oncology (Dordrecht, Netherlands)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 4, 2025

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

Exploring tumor microenvironment interactions and apoptosis pathways in NSCLC through spatial transcriptomics and

Huimin Li¹, Yuheng Jiao², Yi Zhang³

¹Department of Internal Medicine Residency Training Base, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China.

Cellular Oncology (Dordrecht, Netherlands)

|December 19, 2024

Summary

This summary is machine-generated.

Programmed cell death (PCD) pathways are linked to apoptosis and metastasis in non-small cell lung cancer (NSCLC). The gene SLC7A5 is identified as a prognostic indicator and potential therapeutic target for enhancing apoptosis in NSCLC.

Keywords:

Biomarker Cell apoptosis SLC7A5 Single-cell RNA sequencing Spatial transcriptomics

More Related Videos

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

Related Experiment Videos

Last Updated: Jun 4, 2025

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Non-small cell lung cancer (NSCLC) is the most common lung malignancy.
Programmed cell death (PCD) is crucial for cell survival and homeostasis, with growing relevance in cancer research.
Investigating PCD in NSCLC may reveal novel therapeutic strategies.

Purpose of the Study:

To explore the role and mechanisms of programmed cell death (PCD) in non-small cell lung cancer (NSCLC).
To identify genes causally related to PCD in NSCLC and their prognostic significance.
To evaluate SLC7A5 as a potential therapeutic target for NSCLC.

Main Methods:

Utilized GEO and TCGA databases for NSCLC gene expression analysis.
Employed single-cell sequencing and spatial transcriptomics to study PCD mechanisms and tumor microenvironment interactions.
Applied Mendelian randomization, machine learning for prognostic modeling, and in vitro experiments.

Main Results:

High PCD activity in NSCLC cells correlates with apoptosis, cell migration, and hypoxia pathways.
A prognostic model (NSCLCPCD) based on PCD genes shows strong predictive power.
SLC7A5 promotes NSCLC proliferation, and its knockout enhances tumor cell apoptosis.

Conclusions:

Programmed cell death in NSCLC is associated with apoptosis, metastasis, and hypoxia.
SLC7A5 is a significant prognostic indicator for NSCLC.
SLC7A5 represents a potential therapeutic target for increasing apoptosis in NSCLC.