Targeting the GDF15 Signalling for Obesity Treatment: Recent Advances and Emerging Challenges

Area of Science:

• Metabolic research
• Obesity research
• Endocrinology

Background:

• Obesity is a global health crisis requiring novel treatments.
• The Growth Differentiation Factor 15 (GDF15)-Glial cell-derived neurotrophic factor family receptor alpha-like (GFRAL) pathway is integral to metabolic regulation.
• Preserving skeletal muscle mass during weight loss is critical.

Purpose of the Study:

• To review the regulation, distribution, and metabolic roles of the GDF15-GFRAL axis.
• To explore the potential of targeting the GDF15-GFRAL pathway for obesity treatment.
• To discuss recent advancements and challenges in GDF15-GFRAL-targeted obesity therapies.

Main Methods:

• Literature review of preclinical and clinical studies.
• Analysis of GDF15-GFRAL pathway mechanisms.
• Exploration of therapeutic strategies targeting the GDF15-GFRAL axis.

Main Results:

• The GDF15-GFRAL pathway significantly influences appetite and body weight.
• Targeting this pathway shows promise for obesity treatment.
• This approach may preserve skeletal muscle mass during weight reduction.

Conclusions:

• The GDF15-GFRAL axis is a key regulator of energy homeostasis.
• Targeting the GDF15-GFRAL pathway presents a viable strategy for combating obesity.
• Further research is needed to overcome challenges in clinical application.