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Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential

Muluembet Akele1, Matteo Iervolino2, Siska Van Belle1

  • 1Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

Biochimica Et Biophysica Acta. Reviews on Cancer
|December 19, 2024
PubMed

Insights

Lens epithelium-derived growth factor (LEDGF/p75) is a key protein in gene regulation and cancer development. Targeting LEDGF/p75 offers a promising new strategy for cancer chemotherapy.

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • Aberrant gene expression from dysfunctional transcriptional regulators drives tumor development.
  • Lens epithelium-derived growth factor (LEDGF/p75, PSIP1) is a chromatin-tethering co-transcriptional activator.
  • LEDGF/p75 is implicated in HIV infection, KMT2A-rearranged leukemia, and is upregulated in prostate and breast cancers.

Purpose of the Study:

  • To review the critical role of LEDGF/p75 in various malignancies.
  • To explore the mechanistic contribution of LEDGF/p75 to tumorigenesis.
  • To evaluate LEDGF/p75 as a potential therapeutic target in cancer chemotherapy.

Main Methods:

  • Literature review of studies on LEDGF/p75 function in cancer.
  • Analysis of molecular mechanisms linking LEDGF/p75 to tumorigenesis.
  • Evaluation of existing and potential therapeutic strategies targeting LEDGF/p75.

Main Results:

  • LEDGF/p75 plays an essential role in the progression of multiple cancer types.
  • The protein's function in chromatin tethering and co-transcriptional activation contributes to oncogenesis.
  • Upregulation of LEDGF/p75 is observed in common cancers like prostate and breast cancer.

Conclusions:

  • LEDGF/p75 is a significant factor in cancer development and progression.
  • Targeting LEDGF/p75 presents a viable therapeutic strategy for various cancers.
  • Further research into LEDGF/p75 inhibitors could lead to novel chemotherapy treatments.
Keywords:
Epigenetics readerOncogenesisPSIP1Targeted therapy

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