[Analysis of prescription rules for hyperlipidemia comorbid with hypertension based on latent structure model and...

Based on the latent structure model and association rule analysis, the regularity of prescription for hyperlipidemia comorbid with hypertension was explored, and traditional Chinese medicine(TCM) pattern type was speculated to provide a reference for clinical pattern differentiation and treatment, and guideline establishment. The literature on the treatment of hyperlipidemia comorbid with hypertension by TCM was systematically searched on CNKI, Wanfang, VIP, and SinoMed academic platforms. The relevant information was extracted and a database was established using Microsoft Excel 2019. The frequency and properties of high-frequency TCM were statistically analyzed using Lantern 5.0 and RStudio software. The latent structure model and association rule analysis were applied to explore the medication regularity and speculate TCM pattern type. A total of 97 TCM prescriptions involving 104 TCM were included, with a cumulative frequency of 1 189 times. The high-frequency TCM included Poria, Gastrodiae Rhizoma, Atractylodis Macrocephalae Rhizoma, Pinelliae Rhizoma, Citri Reticulatae Pericarpium. The efficacy was mainly based on tonifying deficiency drugs, activating blood circulation drugs, and calming liver wind drugs. A total of 13 latent variables, 42 latent classes, and 5 comprehensive clustering models were obtained from the latent structure analysis. A total of 17 core formulas were obtained, suggesting that there were 5 common patterns in hyperlipidemia comorbid with hypertension, namely phlegm-dampness and blood stasis pattern, phlegm-blood stasis pattern, liver-fire hyperactivity pattern, Yin deficiency and Yang hyperactivity pattern, and liver and kidney deficiency pattern. Association rule analysis obtained 26 strong association rules, among which the highest support degree was Gastrodiae Rhizoma→Poria. Hyperlipidemia comorbid with hypertension belongs to the pattern of deficiency in the root and excess in the branch, which is closely related to the dysfunction of the liver, kidney, and spleen in the body. Phlegm-dampness and blood stasis, liver and kidney Yin deficiency are the main pathogenesis of this disease. The treatment should be based on the principles of calming liver fire, resolving phlegm, and strengthening spleen function. According to the pattern, Qi and blood as well as Yin and Yang should be coordinated to eliminate phlegm, blood stasis, etc., supplemented by treatments such as calming liver fire and eliminating wind from the liver.