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Fungal Group Zygomycota

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...

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Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 4, 2025

Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers

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Published on: September 29, 2023

Dematiaceous Molds.

Lucy X Li¹, Hyunah Yoon²

¹Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Baltimore, MD 21205, USA.

Infectious Disease Clinics of North America

|December 19, 2024

Summary

This summary is machine-generated.

Dematiaceous molds cause various infections in people worldwide. Prompt diagnosis and treatment, including antifungals and source control, are crucial for better outcomes, especially in disseminated cases.

Keywords:

Chromoblastomycosis Dematiaceous molds Emerging molds Eumycetoma Fungal meningitis Opportunistic infections Phaeohyphomycosis

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Published on: September 28, 2021

Area of Science:

Mycology
Infectious Diseases

Background:

Dematiaceous molds are ubiquitous, darkly pigmented fungi found globally, particularly in tropical and subtropical zones.
These fungi, including genera like Bipolaris and Alternaria, cause a spectrum of diseases from superficial infections to life-threatening disseminated disease.
Outbreaks of fungal meningitis have been linked to contaminated medical products, highlighting public health concerns.

Purpose of the Study:

To review the clinical significance of dematiaceous molds.
To discuss their pathogenic potential in both immunocompetent and immunocompromised hosts.
To outline current and potential therapeutic strategies.

Main Methods:

Literature review of dematiaceous mold infections.
Analysis of common genera and their associated diseases.
Summary of treatment modalities and outcomes.

Main Results:

Dematiaceous molds cause cutaneous infections, allergic sinusitis, pneumonia, and rare disseminated infections.
Immunocompromised individuals are at higher risk for severe disease, with high mortality rates, particularly from Lomentospora prolificans.
Contaminated medical products pose a significant risk for outbreaks, such as fungal meningitis.

Conclusions:

Effective management requires a combination of antifungal therapy (e.g., itraconazole, voriconazole, posaconazole), source control, and immunosuppression reduction.
Emerging antifungal agents may offer new treatment options.
Improved diagnostics and novel treatments are urgently needed to combat severe dematiaceous mold infections globally.