Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.2K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
The Thyroid Gland01:23

The Thyroid Gland

3.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.6K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

120
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
120
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

2.9K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlation Between the Controlled Attenuation Parameter and the Prevalence of T2DM in Southern China: A Retrospective Cross-Sectional Study.

Diabetes, metabolic syndrome and obesity : targets and therapy·2025
Same author

Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells.

BioMed research international·2015
Same author

High-performance HfO x /AlO y -based resistive switching memory cross-point array fabricated by atomic layer deposition.

Nanoscale research letters·2015
Same author

A new strategy for TiO2 whiskers mediated multi-mode cancer treatment.

Nanoscale research letters·2015
Same author

Development of benzimidazole derivatives to inhibit HIV-1 replication through protecting APOBEC3G protein.

European journal of medicinal chemistry·2015
Same author

Observer-Based Adaptive Neural Network Control for Nonlinear Systems in Nonstrict-Feedback Form.

IEEE transactions on neural networks and learning systems·2015
Same journal

Obesity-Related Insulin Resistance Indices and CKD Risk in Patients with Diabetes and Coronary Heart Disease: A Multicenter Cohort Analysis.

Diabetes, metabolic syndrome and obesity : targets and therapy·2026
Same journal

Targeting Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs): A Novel Therapeutic Strategy for Diabetic Complications.

Diabetes, metabolic syndrome and obesity : targets and therapy·2026
Same journal

Association Between First-Trimester Gestational Weight Gain and the Risks of Gestational Diabetes Mellitus and Macrosomia.

Diabetes, metabolic syndrome and obesity : targets and therapy·2026
Same journal

Integrated Bioinformatic and Experimental Identification of DHCR24 and NRG1 as Key Cellular Aging Genes in Diabetic Cardiomyopathy.

Diabetes, metabolic syndrome and obesity : targets and therapy·2026
Same journal

Inflammation Mediates the Relationship Between Serum Uric Acid and New-Onset Diabetes Risk in Patients with Coronary Heart Disease: Results from a Multicenter Cohort Study.

Diabetes, metabolic syndrome and obesity : targets and therapy·2026
Same journal

Mediating Role of Plasma Biomarkers Associated with Metabolic Syndrome in Cognitive Decline Among Older Adults.

Diabetes, metabolic syndrome and obesity : targets and therapy·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

767

Correlation Between Thyroid Hormone and Controlled Attenuation Parameters: A Cross-Sectional Population-Based Study.

Sumei Li1, Xingye Wu2, Jingming Yu2

  • 1Department of Endocrinology and Metabolism, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, 530022, People's Republic of China.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|December 20, 2024
PubMed
Summary
This summary is machine-generated.

Thyroid hormones free thyroxine (FT4) and free 3,5,3'-triiodothyronine (FT3) show significant linear and nonlinear relationships with controlled attenuation parameter (CAP) in hepatic steatosis. These findings offer new insights for managing liver steatosis.

Keywords:
controlled attenuation parametersfree 3,5,3′-triiodothyroninefree thyroxinenonalcoholic fatty liver diseasethyroid hormonetransient elastography

More Related Videos

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

529
Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

2.6K

Related Experiment Videos

Last Updated: Jun 4, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

767
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

529
Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

2.6K

Area of Science:

  • Endocrinology
  • Hepatology
  • Medical Diagnostics

Background:

  • Hepatic steatosis, a condition characterized by fat accumulation in the liver, is a growing global health concern.
  • Controlled Attenuation Parameter (CAP) is a non-invasive method used to assess liver fat content.
  • Thyroid hormones play crucial roles in metabolic processes, potentially influencing liver health.

Purpose of the Study:

  • To investigate the relationship between thyroid hormone levels and CAP measurements.
  • To explore the role of thyroid hormones in the development or progression of hepatic steatosis.
  • To provide insights for novel prevention and treatment strategies for fatty liver disease.

Main Methods:

  • Analysis of data from 3461 participants who underwent CAP diagnosis between 2018 and 2023.
  • Utilized multiple linear regression, restricted cubic splines (RCS), and threshold effect analyses.
  • Evaluated associations between free thyroxine (FT4), free 3,5,3'-triiodothyronine (FT3), and CAP values.

Main Results:

  • An inverse linear relationship was observed between FT4 and CAP (coefficient -0.855).
  • A positive linear correlation was found between FT3 and CAP (coefficient 2.182).
  • Nonlinear associations and subgroup analyses revealed complex interactions, particularly in severe liver steatosis and across sexes.

Conclusions:

  • Significant linear and nonlinear relationships exist between FT4, FT3, and CAP.
  • Thyroid hormone levels may significantly impact hepatic steatosis.
  • These findings suggest potential therapeutic targets for liver steatosis management.