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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle Closure Glaucoma: Treatment

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Related Experiment Video

Updated: May 12, 2026

A Mouse Model for Laser-induced Choroidal Neovascularization
07:08

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Inflammatory choroidal neovascularization: An evidence-based update.

Andrea Servillo1, Pierluigi Scandale1, Gloria Oldoni1

  • 1Ophthalmology Unit, IRCSS Ospedale San Raffaele, Via Olgettina 60, Milan 20132, Italy; School of Medicine, Vita-Salute San Raffaele University, Via Olgettina 60, Milan 20132, Italy.

Survey of Ophthalmology
|December 20, 2024
PubMed
Summary
This summary is machine-generated.

Inflammatory choroidal neovascularization (iCNV) causes vision loss and is hard to diagnose. Advanced imaging and combined treatments show promise for managing iCNV, but more research is needed.

Keywords:
Infectious uveitisInflammatory choroidal neovascularizationIntravitreal anti-VEGFNon-infectious uveitisPosterior uveitis treatment

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Area of Science:

  • Ophthalmology
  • Immunology
  • Vascular Biology

Background:

  • Inflammatory choroidal neovascularization (iCNV) is a major cause of vision impairment, often stemming from infectious or noninfectious uveitis.
  • Its development involves Bruch membrane damage, inflammation, and reduced blood flow to the choroid.
  • Diagnosing iCNV is difficult due to overlapping symptoms with other uveitis conditions.

Purpose of the Study:

  • To provide an updated overview of iCNV, consolidating recent research on its epidemiology, pathogenesis, and risk factors.
  • To highlight the role of advanced imaging techniques in iCNV detection and differentiation.
  • To review current and emerging treatment strategies for iCNV.

Main Methods:

  • Comprehensive review of recent scientific literature on iCNV.
  • Emphasis on multimodal imaging, including optical coherence tomography (OCT) and OCT angiography (OCTA).
  • Analysis of treatment efficacy, particularly anti-VEGF agents and anti-inflammatory therapies.

Main Results:

  • iCNV diagnosis is challenging, necessitating advanced imaging like OCT and OCTA for accurate detection.
  • Anti-VEGF therapies are effective, but their combination with anti-inflammatory treatments requires further investigation.
  • Limited randomized clinical trials exist due to iCNV's rarity, leading to reliance on case studies.

Conclusions:

  • Early and accurate diagnosis of iCNV is crucial and achievable with advanced imaging techniques.
  • Integrated treatment approaches combining anti-VEGF and anti-inflammatory strategies are promising but need more research.
  • Further research and standardized guidelines are essential for effective iCNV management.