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Updated: Jun 4, 2025

Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading TED
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Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites.

Lorena Benedetti1, Ruolin Fan2, Aubrey V Weigel1

  • 1HHMI Janelia Research Campus, Ashburn, VA 20147, USA.

Cell
|December 21, 2024
PubMed
Summary

Researchers discovered a network of endoplasmic reticulum-plasma membrane (ER-PM) junctions in dendrites. This structure facilitates long-distance neuronal signal propagation and calcium release, aiding dendritic computations.

Keywords:
Ca(2+)/calmodulin-dependent protein kinase IICaMKIIDrosophila melanogasterER-PM junctionsJunctophilinRyRsVGCCendoplasmic reticulumhippocampal neuronsryanodine receptorsvoltage-gated calcium channelsvolume electron microscopy

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