Related Experiment Video
Updated: Jun 4, 2025

03:53
Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
1.5K
Popliteal plexus block in total knee arthroplasty: a single-center randomized controlled double-blinded trial
Kevin Stebler1, Nadia Elia2,3, Isabelle Zaccaria3
1Department of Anesthesiology, La Tour Hôpital Privé SA, Meyrin, Switzerland.
Regional Anesthesia and Pain Medicine
|December 21, 2024
Summary
Adding a popliteal plexus block to a continuous femoral nerve block reduced early postoperative opioid use in total knee arthroplasty patients. However, the small effect size raises questions about its clinical significance for pain management.
Area of Science:
- Anesthesiology
- Orthopedic Surgery
- Pain Management
Background:
- Postoperative pain management after total knee arthroplasty (TKA) is crucial.
- The efficacy of popliteal plexus blocks in conjunction with femoral nerve blocks for TKA is under investigation.
- Continuous femoral nerve blocks are a common approach for TKA pain control.
Purpose of the Study:
- To evaluate if a popliteal plexus block enhances pain relief following TKA.
- To determine if adding a popliteal plexus block reduces postoperative opioid requirements when combined with a continuous femoral nerve block.
- To assess the impact on pain scores and opioid consumption.
Main Methods:
- A randomized trial involving 66 patients undergoing TKA.
- Intervention group: continuous femoral nerve block + popliteal plexus block (n=32).
- Control group: continuous femoral nerve block alone (n=34).
- Primary endpoint: 12-hour postoperative morphine-equivalent consumption.
Main Results:
- The intervention group showed lower median 12-hour morphine-equivalent consumption (6.1 mg vs. 10 mg, p=0.04).
- Lower pain intensity was observed in the postanesthesia care unit for the intervention group (p=0.01).
- Fewer patients in the intervention group reported lateroposterior knee pain at 12 hours (34.4% vs. 61.8%, p=0.03).
- Benefits diminished after 24 hours.
Conclusions:
- Adding a popliteal plexus block to a continuous femoral nerve block significantly decreases opioid utilization within the first 12 hours post-TKA.
- The observed effect size is small, prompting consideration of its clinical relevance.
- Further research may be needed to optimize multimodal analgesia strategies for TKA.

