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The Yucatan Minipig: A Reliable Model for Studying Unilateral Vocal Fold Paralysis
Samuel L Kaefer1, Haley Calcagno2, Maria Feucht1
1Indiana University School of Medicine (IUSM), Indianapolis, Indiana.
Journal of Voice : Official Journal of the Voice Foundation
|December 21, 2024
Summary
Researchers developed a standardized porcine model for unilateral vocal fold paralysis (UVFP). This model shows characteristic pathophysiology and functional changes, making it suitable for testing new UVFP treatments.
Area of Science:
- Laryngology and Otolaryngology
- Animal Models in Research
- Vocal Cord Physiology
Background:
- Unilateral vocal fold paralysis (UVFP) presents complex pathology with limited human treatment options.
- Developing a reliable large animal model is crucial for investigating experimental UVFP therapies.
Purpose of the Study:
- To establish a standardized porcine model of unilateral vocal fold paralysis (UVFP).
- To characterize the pathophysiology and functional outcomes in this novel animal model.
Main Methods:
- Surgical transection of the recurrent laryngeal nerve (RLN) in Yucatan minipigs.
- Assessment of vocalization, nerve conduction, laryngeal adductor pressure (LAP), muscle volume, and histology.
- Measurements taken at baseline and 7 weeks post-transection.
Main Results:
- Reduced motor unit action potentials and significant decrease in LAP post-transection.
- Voice analysis showed decreased intensity and frequency ranges.
- Histological findings consistent with denervation, including reduced muscle volume and smaller myofibril diameters.
Conclusions:
- The developed porcine model exhibits histopathological and functional changes mirroring human UVFP.
- This model provides a viable platform for systematic research into potential UVFP treatments.
