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Nitrided Ti-6Al-4V: A Catalyst for Increase Mineralization and Osteogenic Marker Expression
Annop Krasaesin1, Suttiporn Pinijsuwan2, Chatdanai Boonruang3
1Biomedical Engineering Institute, Chiang Mai University, Chiang Mai, Thailand.
Journal of Biomedical Materials Research. Part A
|December 22, 2024
Summary
Plasma nitriding of titanium alloy (Ti64) using plasma-based ion implantation (PBII) enhances surface properties and promotes bone cell growth. This modified TiN-Ti64 surface shows improved biocompatibility and antibiofilm activity, making it ideal for dental implants.
Area of Science:
- Biomaterials Science
- Surface Engineering
- Materials Science
Background:
- Plasma nitriding is an effective surface modification technique.
- Titanium alloys (Ti64) are widely used in dental implants.
- Improving the biocompatibility and osseointegration of titanium implants is crucial.
Purpose of the Study:
- To investigate the effects of plasma-based ion implantation (PBII) using nitrogen (N2) and argon (Ar) on the surface of Ti64.
- To evaluate the surface properties, biological responses, and antibiofilm activity of the plasma-nitrided Ti64 (TiN-Ti64).
- To assess the potential of TiN-Ti64 as a surface modification for dental implant applications.
Main Methods:
- Plasma-based ion implantation (PBII) was used to nitride the surface of Ti64 with a N2 and Ar gas mixture.
- Surface composition was analyzed using X-ray photoelectron spectroscopy (XPS).
- In vitro biological responses, including cell adhesion, spreading, proliferation, mineralization, and osteogenic gene expression (BMP2, OCN, OPN, RUNX2) of human alveolar bone cells (hAVs) were evaluated. Antibiofilm activity against Streptococcus aureus was also assessed.
Main Results:
- The plasma-nitrided TiN-Ti64 surface exhibited enhanced hydrophilicity and increased surface hardness compared to untreated Ti64.
- TiN-Ti64 significantly improved hAVs cell adhesion, spreading, proliferation, and mineralization.
- Osteogenic differentiation markers (BMP2, OCN, OPN, RUNX2) were significantly upregulated on TiN-Ti64. The surface also demonstrated antibiofilm activity against Streptococcus aureus.
Conclusions:
- The PBII technique effectively modified the Ti64 surface, creating TiN-Ti64 with superior surface properties and enhanced biological performance.
- The TiN-Ti64 surface promotes osteogenic differentiation and exhibits antibiofilm activity, indicating its potential for dental implant applications.
- Plasma-nitrided Ti64 is a promising candidate for advanced dental implant surface modification.
