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Selective laser sintering for printing bilayer tablets.

Laura Andrade Junqueira1, Atabak Ghanizadeh Tabriz1, Vivek Garg2

  • 1Delta Pharmaceutics Ltd., Chatham, Kent ME4 4TB, UK.

International Journal of Pharmaceutics
|December 22, 2024
PubMed
Summary
This summary is machine-generated.

Selective Laser Sintering (SLS) enables the creation of bilayer tablets with rosuvastatin and acetylsalicylic acid. This advanced 3D printing method successfully produced aligned multi-drug tablets with controlled drug release characteristics.

Keywords:
3D printingBilayer tabletsOral solid dosage formsSelective laser sintering

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Area of Science:

  • Pharmaceutical Technology
  • Additive Manufacturing
  • Materials Science

Background:

  • Selective Laser Sintering (SLS) is an additive manufacturing technique with potential for pharmaceutical applications.
  • Developing multi-drug delivery systems requires precise control over drug release and tablet properties.
  • Traditional tablet manufacturing methods may face challenges in producing complex multi-layered formulations.

Purpose of the Study:

  • To investigate the use of SLS for producing bilayer tablets containing rosuvastatin and acetylsalicylic acid.
  • To optimize SLS parameters for monolithic tablets and assess their impact on drug dissolution, hardness, and friability.
  • To develop and evaluate a novel method for fabricating aligned bilayer tablets using SLS with a 3D-printed casing.

Main Methods:

  • Monolithic tablets of rosuvastatin and acetylsalicylic acid were fabricated using SLS with varying laser intensities.
  • Tablet properties including dissolution, friability, and hardness were evaluated.
  • A new SLS method employing a 3D-printed casing was developed to produce aligned bilayer tablets from different powder blends.

Main Results:

  • Increased laser intensity resulted in denser tablet cores, improved hardness, reduced friability, and slower drug release.
  • The novel SLS method successfully produced completely aligned bilayer tablets.
  • Printing bilayer tablets together showed a minimal impact on drug dissolution compared to monolithic tablets.

Conclusions:

  • Selective Laser Sintering is a feasible technique for manufacturing multi-material drug delivery systems.
  • The developed SLS method allows for the precise fabrication of aligned bilayer tablets with tunable drug release.
  • This approach offers a promising avenue for creating advanced pharmaceutical dosage forms.