[Interictal burden of migraine and its evaluations: a literature review]

Tsubasa Takizawa1, Ryo Takemura2, Hisaka Igarashi3

  • 1Department of Neurology, Keio University School of Medicine.

Insights

Migraine burden continues between attacks, impacting daily life due to anxiety. Calcitonin gene-related peptide (CGRP) antibody treatments may alleviate this interictal burden and improve quality of life.

Area of Science:

  • Neurology
  • Pain Medicine
  • Patient-Reported Outcomes

Background:

  • Migraine is a debilitating neurological disorder.
  • Patient burden extends beyond headache episodes.
  • The interictal period significantly impacts quality of life.

Purpose of the Study:

  • To review the literature on patient burden during the interictal period of migraine.
  • To identify factors contributing to interictal burden.
  • To explore potential therapeutic strategies for interictal migraine burden.

Main Methods:

  • Targeted literature review.
  • Analysis of studies focusing on the interictal phase of migraine.
  • Synthesis of findings on patient-reported outcomes and quality of life.

Main Results:

  • Migraine-associated burden persists during the interictal period.
  • Anxiety regarding headache recurrence negatively affects daily activities and quality of life.
  • Prophylactic treatment with calcitonin gene-related peptide (CGRP) antibody drugs shows potential in reducing interictal burden.

Conclusions:

  • Patient burden in migraine is a continuous issue, not limited to headache phases.
  • Addressing interictal burden is crucial for comprehensive migraine management.
  • Personalized treatment selection based on individual patient burden, including interictal experiences, is recommended.

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