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Published on: June 2, 2014
[Interictal burden of migraine and its evaluations: a literature review]
Tsubasa Takizawa1, Ryo Takemura2, Hisaka Igarashi3
1Department of Neurology, Keio University School of Medicine.
Abstract:
We conducted a targeted literature review on patient burden during the interictal period of migraine. The results of the literature review revealed that: (1) migraine-associated burden persists into the interictal period and is not confined to the headache episodes themselves; (2) anxiety over the possible recurrence of headache episodes is a factor that reduces daily activities and quality of life (QOL); and (3) prophylactic treatment with calcitonin gene-related peptide (CGRP) antibody drugs may reduce the burden during the interictal period. From these findings, it is considered important in migraine treatment to identify the unmet needs of patients, including the burden during the interictal period, and to select an appropriate treatment method based on the burden experienced by individual patients.
Insights
Migraine burden continues between attacks, impacting daily life due to anxiety. Calcitonin gene-related peptide (CGRP) antibody treatments may alleviate this interictal burden and improve quality of life.
Area of Science:
- Neurology
- Pain Medicine
- Patient-Reported Outcomes
Background:
- Migraine is a debilitating neurological disorder.
- Patient burden extends beyond headache episodes.
- The interictal period significantly impacts quality of life.
Purpose of the Study:
- To review the literature on patient burden during the interictal period of migraine.
- To identify factors contributing to interictal burden.
- To explore potential therapeutic strategies for interictal migraine burden.
Main Methods:
- Targeted literature review.
- Analysis of studies focusing on the interictal phase of migraine.
- Synthesis of findings on patient-reported outcomes and quality of life.
Main Results:
- Migraine-associated burden persists during the interictal period.
- Anxiety regarding headache recurrence negatively affects daily activities and quality of life.
- Prophylactic treatment with calcitonin gene-related peptide (CGRP) antibody drugs shows potential in reducing interictal burden.
Conclusions:
- Patient burden in migraine is a continuous issue, not limited to headache phases.
- Addressing interictal burden is crucial for comprehensive migraine management.
- Personalized treatment selection based on individual patient burden, including interictal experiences, is recommended.
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