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Fast and Accurate Exhaled Breath Ammonia Measurement
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Ammonium Sensing Patch with Ultrawide Linear Range and Eliminated Interference for Universal Body Fluids Analysis.

Mingli Huang1, Xiaohao Ma1,2, Zongze Wu3

  • 1School of Microelectronics, Southern University of Science and Technology, Shenzhen, 518055, People's Republic of China.

Nano-Micro Letters
|December 22, 2024
PubMed
Summary

A new flexible sensor patch enables wireless, real-time monitoring of ammonium levels in various body fluids. This breakthrough offers reliable and selective biomarker analysis for diverse healthcare applications.

Keywords:
Ammonium sensingBiocompatible sensorsCross-calibrationImplantable bioelectronicsUltrawide linear range

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Area of Science:

  • Biomedical Engineering
  • Biosensors
  • Wearable Technology

Background:

  • Ammonium levels are critical biomarkers, especially for liver disease diagnosis.
  • Current monitoring methods face challenges with varying concentrations across body fluids and interference from other ions like potassium.
  • Continuous, real-time sensing in both invasive and non-invasive ways is highly desirable for effective healthcare.

Purpose of the Study:

  • To develop a flexible and biocompatible sensing patch for wireless ammonium level monitoring.
  • To achieve an ultrawide linear range for sensing ammonium in diverse body fluids.
  • To ensure reliable and selective ammonium detection, overcoming interference from potassium ions.

Main Methods:

  • Fabrication of a flexible and biocompatible sensing patch.
  • Utilizing an array of sensors with cross-calibration for enhanced selectivity.
  • Validation of sensor biocompatibility through cell growth assays, hemolysis tests, and in-vivo studies in mice.

Main Results:

  • The sensor patch demonstrated an ultrawide linear range for ammonium detection (1-100 mM).
  • Achieved a reliable sensitivity of 58.7 mV/decade and a selectivity coefficient of 0.11 against potassium ion interference.
  • Validated excellent biocompatibility with cell growth >80%, hemolysis <5%, and negligible inflammatory responses.

Conclusions:

  • The developed sensing patch offers a versatile platform for continuous, wireless ammonium monitoring across various body fluids.
  • The sensor's ultrawide linear range, high sensitivity, and selectivity provide a reliable solution for biomarker analysis.
  • This technology opens new possibilities for highly compatible and versatile biomarker detection in healthcare.