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Dynamic Co-Clustering and Self-Sorting in Interactive Protocell Populations.

Ananya Mishra^1,2, Hannah Taylor¹, Avinash J Patil¹

¹Centre for Protolife Research and Centre for Organized Matter Chemistry, School of Chemistry, University of Bristol, Bristol, BS8 1TS, United Kingdom.

Angewandte Chemie (International Ed. in English)

|December 23, 2024

Summary

This summary is machine-generated.

Researchers created hairy catalytic protocells that self-organize. This self-organization, specifically co-clustering, improves signal transmission in protocell communities, advancing synthetic biology.

Keywords:

biocatalysis hairy protocells homotypic and heterotypic interactions interprotocellular communication polymer coated colloidosomes

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Area of Science:

Synthetic biology
Protocell research
Biomaterials science

Background:

Collective action in protocell communities presents significant challenges.
Developing life-like adaptive materials requires understanding protocell organization.

Purpose of the Study:

To engineer catalytic protocells capable of collective action.
To investigate stimulus-responsive spatial organization in protocell communities.
To enhance signal transmission within artificial cell networks.

Main Methods:

Covalently grafting alginate or chitosan onto silica colloidosomes to create hairy catalytic protocells.
Utilizing pH-switchable surface charge for stimulus-responsive organization.
Analyzing self-sorting and co-clustering behaviors in binary protocell populations.
Quantifying signal attenuation and proximity effects in sender-receiver protocell systems.

Main Results:

Hairy catalytic protocells with pH-switchable surface charge were successfully produced.
Binary protocell populations demonstrated self-initiated, stimulus-responsive spatial organization, including self-sorting and co-clustering.
Co-clustering, unlike self-sorting, mitigated signal attenuation by increasing protocell proximity.
Signal attenuation was correlated with pH-mediated changes in spatial organization.

Conclusions:

Engineered protocells can exhibit collective behaviors like self-sorting and co-clustering.
Co-clustering enhances intercellular communication in synthetic protocell communities.
These findings support the development of programmable networks of adaptive, life-like objects and cytomimetic materials.