Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Formation of Complex Ions

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

Mass Spectrometry: Complex Analysis

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...

Complexometric Titration: Ligands

Complexometric Titration: Ligands

Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...

Combining Functions

Combining Functions

Functions can be combined to form new mathematical models that describe interactions between variables. These combinations are fundamental in understanding relationships between changing quantities and are commonly encountered in scientific and engineering contexts. The combination methods—addition, subtraction, multiplication, division, and composition—each have unique implications for the resulting function’s domain and behavior.When combining functions through arithmetic operations, such...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Zn(II)-Responsive Peptide Hydrogels with Tunable Mechanical Properties.

ACS omega·2026

Same author

High-throughput triazole-based combinatorial click chemistry for the synthesis and identification of functional metal complexes.

Nature communications·2025

Same author

ELECTRUM: an electron configuration-based universal metal fingerprint for transition metal compounds.

Digital discovery·2025

Same author

Synthesis of a macrocyclic and medium-sized ring lactam library using cascade ring expansion reactions.

Organic & biomolecular chemistry·2025

Same author

The ubiquitous P(<i>o</i>-tol)<sub>3</sub> ligand promotes formation of catalytically-active higher order palladacyclic clusters.

Chemical science·2024

Same author

Revealing the Hidden Complexity and Reactivity of Palladacyclic Precatalysts: The P(<i>o</i>-tolyl)<sub>3</sub> Ligand Enables a Cocktail of Active Species Utilizing the Pd(II)/Pd(IV) and Pd(0)/Pd(II) Pathways for Efficient Catalysis.

ACS catalysis·2024

Same journal

The Role of Zn-Hf Site Proximity and Oxygen Vacancies for Methanol Formation Over ZnHfO<sub>x</sub> Catalysts Under CO<sub>2</sub> Hydrogenation Conditions.

Angewandte Chemie (International ed. in English)·2026

Same journal

Breaking the Linear Scaling Relationship: Bioinspired Electronic Coupling in S-Bridged Fe-Fe Dual Sites for Efficient Oxygen Reduction.

Angewandte Chemie (International ed. in English)·2026

Same journal

Programming Bio-Bio Electronic Interfaces for Light-Driven Interspecies Electron Transfer.

Angewandte Chemie (International ed. in English)·2026

Same journal

Self-Cleaning Solar Evaporation Facilitating Water Electrolysis for Hydrogen Generation From Seawater.

Angewandte Chemie (International ed. in English)·2026

Same journal

Sulfur Vacancy-Enriched Cu<sub>4</sub>SnS<sub>4-x</sub> Nanosheets Enable Synergistic Cuproptosis, Photothermoelectric Catalytic and Immunotherapy.

Angewandte Chemie (International ed. in English)·2026

Same journal

Mechanically Interlocked Indigo Photoswitches.

Angewandte Chemie (International ed. in English)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

Published on: July 8, 2015

High-Throughput Combinatorial Metal Complex Synthesis.

A Welsh^1,2, D Husbands², A Frei^1,2

¹Department of Chemistry, Biochemistry & Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland.

Angewandte Chemie (International Ed. in English)

|December 23, 2024

Summary

This summary is machine-generated.

High-throughput combinatorial metal complex synthesis rapidly generates diverse metal complexes for accelerated discovery in catalysis, medicine, and materials science. Advancements in automation and AI enhance efficiency, overcoming challenges in scalability and purity.

Keywords:

Combinatorial Synthesis High-Throughput Machine Learning Metal Complexes

More Related Videos

Synthesis of a Water-soluble Metal–Organic Complex Array

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

Related Experiment Videos

Last Updated: Jun 20, 2026

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

Generation of Scalable, Metallic High-Aspect Ratio Nanocomposites in a Biological Liquid Medium

Published on: July 8, 2015

Synthesis of a Water-soluble Metal–Organic Complex Array

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

Area of Science:

Inorganic Chemistry
Materials Science
Medicinal Chemistry

Background:

High-throughput combinatorial synthesis is a key technique for discovering novel metal complexes.
Diverse libraries of metal complexes are crucial for advancements in various scientific fields.
Traditional synthesis methods can be time-consuming and limit the exploration of chemical space.

Purpose of the Study:

To highlight the significance of high-throughput combinatorial metal complex synthesis.
To discuss its applications in catalysis, medicinal chemistry, and materials science.
To outline the benefits of integrating this method with screening and data-driven approaches.

Main Methods:

Systematic combination of building blocks under mild and efficient conditions.
Generation and screening of diverse libraries of metal complexes.
Integration with high-throughput screening and machine learning for data analysis.

Main Results:

Accelerated discovery of metal complexes with desired properties.
Streamlined hit identification and optimization processes.
Exploration of broad chemical spaces for novel applications.

Conclusions:

High-throughput combinatorial synthesis is a powerful tool for rapid discovery.
Advancements in automation and predictive modeling are improving efficiency.
This approach opens new avenues for developing metal-based catalysts, therapeutics, and materials.