Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

2.0K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
2.0K
Production of Antibiotics01:27

Production of Antibiotics

265
Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
265
Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

77
Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
77

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of the safety and potential genotoxicity of a high-purity mogroside ingredient containing siamenoside I produced from a modified strain of <i>Yarrowia lipolytica</i>.

Toxicology reports·2026
Same author

Protein content of glycerinated extracts and commercial food products for priority allergens relevant to sublingual immunotherapy.

The journal of allergy and clinical immunology. In practice·2026
Same author

Effectiveness of a Provincial Law to Improve Epinephrine Use for Anaphylaxis in Schools in Alberta, Canada: A Pre-Post Study.

International archives of allergy and immunology·2026
Same author

Enhancing access to a pediatric surgical specialty through virtual care and outreach clinics: A pilot quality improvement initiative at a tertiary children's hospital.

Journal of pediatric surgery·2026
Same author

Comparative <i>in vitro</i> Metabolism of Siamenoside I and Monk Fruit Extract.

International journal of toxicology·2026
Same author

Safety of home-based oral immunotherapy in highly-sensitized preschoolers with a simplified protocol.

The journal of allergy and clinical immunology. In practice·2026

Related Experiment Video

Updated: May 1, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.3K

Developing and disseminating an electronic penicillin allergy de-labelling tool using the model for improvement

Sujen Saravanabavan1, Patrick McKernan2, Scott Cameron3,4

  • 1BC Children's Hospital, 4480 Oak Street, Room 1C31B, Oak Street Entrance, 1982 Building, Djavid Mowafaghian Wing, Vancouver, BC, V6H 3V4, Canada. sujen.saravanabavan@gmail.com.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|December 24, 2024
PubMed
Summary

A new electronic tool improved clinician intent to perform penicillin allergy de-labelling oral challenges by over 15%. The tool also enhanced provider satisfaction and confidence in risk stratification for penicillin allergies.

Keywords:
Antibiotic allergyClinicalDecision support systemsDrug hypersensitivityPatient safetyPenicillin allergyPenicillin hypersensitivityQuality improvement

More Related Videos

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
06:40

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

Published on: June 29, 2019

6.5K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.4K

Related Experiment Videos

Last Updated: May 1, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.3K
The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
06:40

The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

Published on: June 29, 2019

6.5K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.4K

Area of Science:

  • Clinical Informatics
  • Allergy and Immunology
  • Quality Improvement Science

Background:

  • Many clinicians hesitate to de-label penicillin allergies despite safety data.
  • Electronic point-of-care tools can support providers in allergy de-labelling.
  • This study aimed to increase provider intent for penicillin oral challenges by 15%.

Purpose of the Study:

  • To assess the impact of an electronic point-of-care tool on clinician intent to perform penicillin allergy de-labelling.
  • To evaluate provider satisfaction and confidence with the tool's risk-stratification capabilities.
  • To improve the adoption and effectiveness of penicillin allergy de-labelling protocols.

Main Methods:

  • A validated de-labelling algorithm was integrated into an electronic point-of-care tool.
  • The tool was implemented across eight healthcare institutions using the Model for Improvement Framework and three PDSA cycles.
  • Data on provider intent, tool usage, satisfaction, and confidence were collected and analyzed.

Main Results:

  • Provider intent for penicillin oral challenges increased from 50.4% to 65.5% after tool implementation (15.1% increase).
  • Monthly tool usage increased from 61.3 to 98.6 uses.
  • Provider satisfaction rose to 100%, and confidence in risk stratification reached 98.1% with the improved tool version.

Conclusions:

  • The quality improvement initiative successfully increased provider intent for penicillin allergy de-labelling.
  • The electronic tool significantly enhanced provider satisfaction and confidence in risk stratification.
  • Integrating electronic tools into institutional protocols is recommended for effective penicillin allergy de-labelling.