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Effect of flecainide on cardiac output
Clinical Pharmacology and Therapeutics
|March 1, 1985
Summary
Intravenous flecainide (2 mg/kg) temporarily decreased cardiac output and stroke volume in healthy individuals. Heart rate initially increased, while alertness decreased, but dry mouth was not observed.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Flecainide is an antiarrhythmic medication.
- Understanding its hemodynamic effects is crucial for patient safety.
Purpose of the Study:
- To evaluate the impact of intravenous flecainide on cardiac output in healthy subjects.
- To assess associated changes in heart rate, stroke volume, and subjective side effects.
Main Methods:
- Double-blind, crossover, placebo-controlled, randomized, and balanced study design.
- Dye dilution method used for cardiac output measurement.
- Measurements taken at multiple time points up to 240 minutes post-infusion.
Main Results:
- Flecainide (2 mg/kg IV) reduced cardiac output and stroke volume within the initial 90 minutes.
- Heart rate showed a transient increase in the first 30 minutes.
- Alertness was diminished at 60 minutes; dry mouth was not reported.
Conclusions:
- Intravenous flecainide has transient negative effects on cardiac function in healthy individuals.
- Subjective side effects like dry mouth are unlikely at this dosage, but alertness may be affected.