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Related Concept Videos

Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

898
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
898

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Related Experiment Video

Updated: Jun 4, 2025

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
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Deep Septal Pacing for Pacemaker-Induced Cardiomyopathy.

Jordi Mercé1,2, Ignasi Anguera1,2, Marcos Rodríguez1,2

  • 1Servei de Cardiologia, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.

Pacing and Clinical Electrophysiology : PACE
|December 24, 2024
PubMed
Summary

Deep septal pacing (DSP) offers a simpler alternative for patients with pacing-induced cardiomyopathy (PICM). This study found DSP effectively improved left ventricular function and reduced QRS duration compared to conventional right ventricular pacing.

Keywords:
cardiac pacingcardiac resynchronizationconduction system pacingheart failureleft bundle branch area pacingpacing‐induced cardiomyopathy

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure

Background:

  • Right ventricular (RV) pacing can lead to pacing-induced cardiomyopathy (PICM), impairing left ventricular function.
  • Cardiac resynchronization therapy (CRT) and left bundle branch area pacing (LBBAP) are current treatments.
  • Deep septal pacing (DSP) presents a simplified approach to LBBAP.

Purpose of the Study:

  • To evaluate the efficacy of deep septal pacing (DSP) in patients diagnosed with pacing-induced cardiomyopathy (PICM).

Main Methods:

  • Consecutive patients with PICM were enrolled for upgrade to DSP.
  • Procedure success was defined by paced QRS duration ≤140 ms without a terminal R wave in V1.
  • Twelve patients with baseline LVEF of 33% and 99% RV pacing underwent the upgrade.

Main Results:

  • DSP significantly narrowed paced QRS duration from 172 ms to 130 ms (p < 0.001).
  • Left ventricular ejection fraction (LVEF) improved from 33% to 46% at 6 months (p = 0.001).
  • Eleven out of twelve patients showed at least a 5% improvement in LVEF.

Conclusions:

  • Deep septal pacing (DSP) appears to be an effective and simpler alternative for treating pacing-induced cardiomyopathy (PICM).
  • Achieving narrower paced QRS complexes with DSP can potentially improve left ventricular function.