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Maxam-Gilbert Sequencing

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...

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Related Experiment Video

Updated: May 8, 2025

Large-Scale Screens of Metagenomic Libraries

Large-Scale Screens of Metagenomic Libraries

Published on: May 28, 2007

DNA-encoded chemical libraries on stage

Andreas Gloger¹, Jörg Scheuermann²

¹Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland. andreas.gloger@pharma.ethz.ch.

Nature Chemical Biology

|December 24, 2024

Summary

No abstract available in PubMed .

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