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Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report
S Asad1, K Latifzai2, V T Eliopoulos2
1Baptist Medical Center, Jacksonville, FL, USA.
Journal of Medical Case Reports
|December 24, 2024
Summary
Ketamine infusions provided significant symptom relief for patients with chronic posttraumatic stress disorder and major depressive disorder. Electrophysiological changes observed suggest altered brain function, offering hope for refractory conditions.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Ketamine offers a novel treatment for refractory conditions like major depressive disorder (MDD) and posttraumatic stress disorder (PTSD).
- These conditions often co-occur, presenting significant clinical challenges.
- This study investigates the clinical and electrophysiological effects of ketamine in two complex cases.
Observation:
- Two cases presented: a male with chronic PTSD and suicidal ideation, and a female with treatment-resistant MDD.
- Both patients underwent ketamine infusions after extensive unsuccessful treatments.
- Electrophysiological changes (EEG, evoked EEG) were monitored alongside symptom progression.
Findings:
- Ketamine infusions led to significant and lasting symptom improvement in both patients.
- Distinct electrophysiological alterations were observed, indicating changes in brain function.
- These observed changes persisted for several months post-treatment.
Implications:
- Ketamine shows potential as an alternative therapy for refractory MDD and PTSD.
- The findings suggest ketamine may offer relief and functional recovery for specific patient populations.
- Further research is needed to understand mechanisms and optimize ketamine treatment protocols.
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