Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-omics analysis of the gill-gut axis in Scylla paramamosain under acute low-salinity stress: Implications for ion and osmotic regulation.

Marine environmental research·2026
Same author

Supramolecular Photosensitizers: From Engineering Principles to Functional Applications.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Potentials of Machine Learning in Predicting Key Features of Synthetic Antimicrobial Polymers.

ACS polymers Au·2026
Same author

Integrating Transcriptomics and Gut Microbiota Analysis Reveals Adaptive Mechanisms of Alkaline Stress on the Molting and Intestinal Immune Responses in Pacific White Shrimp, <i>Litopenaeus vannamei</i>.

Life (Basel, Switzerland)·2026
Same author

Neutron reflectometry instrumentation at the ISIS source: current state.

Journal of applied crystallography·2026
Same author

Selective Serine Substitutions of Antimicrobial Peptides Reveal Different Mechanistic Actions Toward Gram-Negative Bacteria.

ACS applied materials & interfaces·2026

Related Experiment Video

Updated: Jun 4, 2025

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

8.1K

pH-Responsive nanotubes from asymmetric cyclic peptide-polymer conjugates.

Zihe Cheng1, Qiao Song2, Stephen C L Hall3

  • 1Department of Chemistry, University of Warwick Coventry CV4 7AL UK s.perrier@warwick.ac.uk.

Chemical Science
|December 25, 2024
PubMed
Summary

Novel pH-responsive nanotubes were created using cyclic peptide-polymer conjugates. These self-assembling systems offer tunable properties for applications like drug delivery by responding to environmental pH changes.

More Related Videos

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
08:00

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

6.9K
Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

9.1K

Related Experiment Videos

Last Updated: Jun 4, 2025

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

8.1K
DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
08:00

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

6.9K
Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering
09:12

Functionalization of Single-walled Carbon Nanotubes with Thermo-reversible Block Copolymers and Characterization by Small-angle Neutron Scattering

Published on: June 1, 2016

9.1K

Area of Science:

  • Supramolecular chemistry
  • Materials science
  • Polymer chemistry

Background:

  • Self-assembling cyclic peptide nanotubes show promise for drug delivery and biomimetic systems.
  • Controlling nanotube formation is key to unlocking their potential applications.

Purpose of the Study:

  • To develop novel pH-responsive cyclic peptide nanotubes using asymmetric peptide-polymer conjugates.
  • To investigate the influence of polymer hydrophobicity and properties on nanotube self-assembly and stability.

Main Methods:

  • Synthesis of cyclic peptide-polymer conjugates with pH-responsive polymers (pDMAEMA, pDEAEMA).
  • Investigation of self-assembly using scattering and spectroscopy techniques.
  • Analysis of pH-triggered assembly/disassembly mechanisms.

Main Results:

  • Hydrophobic polymer chains promote longer nanotube formation by preventing water penetration.
  • pH triggers nanotube assembly/disassembly via hydrophobic interactions and electrostatic repulsions.
  • Polymer properties (composition, protonation, molecular weight) significantly affect self-assembly behavior.

Conclusions:

  • Asymmetric cyclic peptide-polymer conjugates offer a versatile platform for creating pH-responsive self-assembling nanotubes.
  • The study elucidates the structure-property relationships governing the self-assembly of these advanced nanomaterials.
  • These findings pave the way for designing smart nanomaterials for targeted applications.