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Updated: Jul 14, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Diffuse Large B-cell Lymphoma with a Multilobated Nuclear Morphology Harboring t(14;18)(q32;q21) and t(3;22)(q27;q11)
Masahiro Manabe1, Naoyuki Inano2, Yuuji Hagiwara2
1Department of Hematology, Osaka General Hospital of West Japan Railway Company, Japan.
Abstract:
A 70-year-old woman was admitted to our hospital with dyspnea. Atypical cells with multilobated nuclei were observed in the pleural effusion. Diffuse large B-cell lymphoma (DLBCL) was diagnosed based on a cell block analysis. A chromosomal analysis of lymphoma cells revealed t(14;18)(q32;q21) and t(3;22)(q27;q11). The patient's disease was refractory to chemotherapy, and she died within one year. Although flower-like nuclei are typical of adult T-cell lymphoma/leukemia, similar multilobated nuclei may occur in DLBCL. Although multilobated DCBCL have been reported to have a better prognosis than other forms of DLBCL, the abovementioned translocations may have contributed to the patient's aggressive clinical course.
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