[Long-Term Survival in Esophagogastric Junction Cancer with Multiple Lymph Node Metastasis Through Pre-and-Post...

A 62-year-old man was diagnosed with Stage Ⅲ signet ring cell carcinoma of the lower thoracic esophagus. The patient underwent 2 courses of neoadjuvant cisplatin and 5-fluorouracil(SP therapy), demonstrating stable efficacy. Subsequently, the patient underwent subtotal esophagectomy with thoracoabdominal 2-field lymphadenectomy via right thoracotomy, followed by esophageal reconstruction using a gastric tube through a retrosternal route. Pathological examination revealed a signet ring cell carcinoma of the esophagogastric junction(pT3, pN2, sM0, and fStage Ⅲ). Postoperatively, the patient received chemotherapy with S-1 for 2 years owing to multiple lymph node metastases. Remarkably, the patient remained free of recurrence 6 years after surgery. We encountered a case of long-term survival in esophagogastric junction cancer with multiple lymph node metastases, typically associated with poor prognosis, following pre- and postoperative chemotherapy and radical surgery.