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Related Experiment Video

Updated: Jun 4, 2025

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Preclinical RA: How to halt its progression.

Tong Wu1, Yanhong Li1, Yi Liu2

  • 1Department of Rheumatology and Immunology, Laboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

Best Practice & Research. Clinical Rheumatology
|December 25, 2024
PubMed
Summary

This review details rheumatoid arthritis (RA) progression from genetic and environmental factors to preclinical autoimmunity. Early interventions targeting preclinical RA may prevent disease onset.

Keywords:
At-risk for RAPreclinical RAPreventionRheumatoid arthritis

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Area of Science:

  • Immunology
  • Rheumatology
  • Autoimmune Diseases

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease with a complex, multi-stage pathogenesis.
  • Disease progression involves genetic predisposition, environmental triggers, and preclinical autoimmunity before clinical symptoms.

Purpose of the Study:

  • To review the natural history of rheumatoid arthritis.
  • To highlight opportunities for intervention during preclinical stages.

Main Methods:

  • Literature review of rheumatoid arthritis pathogenesis.
  • Analysis of genetic and environmental factors contributing to RA development.

Main Results:

  • Autoantibodies like anti-citrullinated protein antibodies (ACPA) and rheumatoid factor precede clinical RA by years.
  • Preclinical autoimmunity is a critical window for potential disease interception.

Conclusions:

  • Understanding RA's natural history is key to developing preventive strategies.
  • Interventions such as lifestyle changes and immune modulation may halt progression in at-risk individuals.