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Endocrine disruptors and bladder function: the role of phthalates in overactive bladder
Li Liu1, Xia Li1, Xuexue Hao1
1Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
Frontiers in Public Health
|December 26, 2024
Summary
Higher urinary phthalate levels, specifically mono-benzyl phthalate (MBzP) and mono-isobutyl phthalate (MiBP), are linked to increased overactive bladder (OAB) risk. These environmental contaminants may play a role in OAB development.
Area of Science:
- Environmental Health
- Urology
- Endocrinology
Background:
- Phthalates are common plasticizers and endocrine disruptors found in the environment.
- Their role in overactive bladder (OAB) pathogenesis is not well understood.
- Large-scale epidemiological data is needed to investigate phthalate exposure and OAB.
Purpose of the Study:
- To examine the association between urinary phthalate concentrations and OAB.
- To explore potential non-linear relationships and mixture effects of phthalates on OAB.
- To identify specific phthalates contributing to OAB risk.
Main Methods:
- Utilized National Health and Nutrition Examination Survey (NHANES) data (2011-2018).
- Employed weighted multivariable logistic regression, restricted cubic spline (RCS), and Bayesian Kernel Machine Regression (BKMR) analyses.
- Investigated associations between urinary phthalate metabolites (MBzP, MiBP) and OAB, including subgroup and mixture analyses.
Main Results:
- Higher concentrations of mono-benzyl phthalate (MBzP) and mono-isobutyl phthalate (MiBP) were significantly associated with increased OAB risk.
- RCS analysis indicated a linear relationship between MBzP, MiBP, and OAB.
- BKMR analysis confirmed a positive overall effect of phthalate mixtures on OAB, with MBzP as a key contributor.
Conclusions:
- A positive correlation exists between urinary phthalate concentrations and OAB.
- MBzP and MiBP are potential contributors to OAB pathogenesis.
- Further research is warranted to validate and refine these findings on phthalates and OAB.
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