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Exploring Genetic Association of Tea Intake With Allergic Diseases Among European Population: A Bidirectional
Jinjin Zhang1,2, Yuhan Liu3, Jiawei Zhang2,4
1Department of Pain Medicine Ji'an Central People's Hospital Ji'an China.
Food Science & Nutrition
|December 26, 2024
Summary
Increased tea consumption may causally reduce the risk of atopic dermatitis (AD) and allergic asthma (AA). However, this study found no significant causal link between tea intake and allergic rhinitis (AR).
Area of Science:
- Genetics
- Epidemiology
- Immunology
Background:
- Observational studies suggest a link between tea intake and allergic diseases, but causality remains unproven.
- Mendelian randomization (MR) is a robust method for investigating causal relationships using genetic variants.
Purpose of the Study:
- To investigate the causal effect of genetically predicted tea intake on the risk of atopic dermatitis (AD), allergic rhinitis (AR), and allergic asthma (AA).
Main Methods:
- Utilized a bidirectional Mendelian randomization (MR) design with 40 independent single-nucleotide polymorphisms (SNPs) for tea intake as instrumental variables (IVs).
- Data from 447,485 UK Biobank samples were analyzed.
- Inverse variance weighted (IVW) method was the primary analysis, with MR Egger and MR-PRESSO for sensitivity analyses.
Main Results:
- Genetically predicted higher tea intake was associated with a significantly lower risk of AD (OR=0.709, p=0.009) and AA (OR=0.498, p=0.002).
- No significant causal association was found between tea intake and AR (OR=1.008, p=0.115).
Conclusions:
- Increased tea intake may have a protective causal effect against atopic dermatitis and allergic asthma in the European population.
- Tea consumption could be a potential preventative strategy for AD and AA.
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