Related Experiment Video
Updated: May 8, 2025
14:09
In vitro Functional Characterization of Mouse Colorectal Afferent Endings
Published on: January 21, 2015
9.5K
Nervous system in colorectal cancer.
Chunjie Xu1, Chunhui Jiang1, Yuan Tian1
1Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, China.
Cancer Letters
|December 26, 2024
Summary
Cancer neuroscience explores how tumors interact with the nervous system. This review details tumor-nerve interactions in colorectal cancer (CRC), impacting its progression.
Area of Science:
- Neuroscience
- Oncology
- Gastroenterology
Background:
- Malignant tumors are complex systemic diseases involving the nervous system.
- Cancer neuroscience studies tumor-nervous system interactions.
- The gastrointestinal tract, regulated by the peripheral, enteric, and central nervous systems, is susceptible to neuroregulatory imbalance, leading to diseases like colorectal cancer (CRC).
Purpose of the Study:
- To review basic knowledge of cancer neuroscience.
- To elucidate the mechanisms of tumor-nerve interactions in CRC.
- To highlight the role of the nervous system in CRC development and progression.
Main Methods:
- Literature review of cancer neuroscience and CRC.
- Analysis of neuroregulatory mechanisms in the gastrointestinal tract.
- Examination of direct and indirect tumor-nerve interactions.
Main Results:
- Tumor-nerve interactions directly affect CRC cells.
- These interactions indirectly modulate the tumor microenvironment (microbiota, immunity, metabolism).
- Higher nerve centers (stress, emotion, cognition) also influence CRC occurrence and progression.
Conclusions:
- The nervous system plays a critical role in CRC.
- Understanding tumor-nerve interactions is crucial for CRC management.
- Cancer neuroscience offers insights into CRC pathogenesis and potential therapeutic strategies.
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