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Risk Factors of Hypersensitivity Reactions to Carboplatin: A Systematic Review and Meta-Analysis
Ha Young Jang1, Boyoon Choi2, In-Wha Kim3
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea; College of Pharmacy, Gachon University, Incheon, South Korea.
Hypersensitivity reactions to carboplatin are common. Key risk factors include allergies, BRCA mutations, longer treatment breaks, higher doses, relapse, and younger age, aiding personalized risk assessment.
Area of Science:
- Oncology
- Pharmacology
- Clinical Medicine
Background:
- Hypersensitivity reactions (HSRs) to carboplatin complicate cancer treatment and survival.
- Previous studies on carboplatin HSR risk factors yielded inconclusive results.
Purpose of the Study:
- To systematically review and perform a meta-analysis to identify consensus risk factors for carboplatin HSRs in cancer patients.
- To provide a comprehensive quantitative evaluation of these risk factors.
Main Methods:
- Systematic review and meta-analysis following PRISMA guidelines.
- Searched MEDLINE, Embase, and Korean Medical Database for case-control or cohort studies.
- Included 19 studies after quality assessment using the Newcastle-Ottawa scale.
Main Results:
- Identified risk factors for carboplatin HSRs: history of allergies (OR=1.76), BRCA mutation (OR=4.03), carboplatin-free interval ≥12 months (OR=4.93).
- Other factors include increased cumulative dose (SMD=0.58), relapse (OR=2.26), and younger age (SMD=-0.15).
Conclusions:
- This meta-analysis offers a comprehensive evaluation of carboplatin HSR risk factors.
- Findings can inform personalized risk assessment and preventive strategies for improved patient safety and outcomes.
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