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Updated: Jun 4, 2025

Author Spotlight: A Reproductive Hysteroscopy Approach for Complete Endometrial Polyp Removal and Enhanced Endometrial Receptivity
Published on: August 2, 2024
Cold- versus hot-snare endoscopic mucosal resection of colorectal polyps: meta-analysis of randomized controlled
Aamir Saeed1, Saira Yousuf1, Nicholas Noverati2
1Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Background And Aims:
Interest in cold endoscopic mucosal resection (EMR) for colorectal polyps has been growing. We conducted a meta-analysis of randomized controlled trials to compare cold and hot EMR for colorectal polyps.
Methods:
We reviewed several databases from inception to October 6, 2024. Outcomes of interest were recurrent or residual neoplasia, en-bloc resection, incomplete resection, perforation, and intraprocedural and delayed bleeding. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated by means of a random-effects model.
Results:
Rate of recurrent or residual neoplasia was significantly higher in the cold EMR group: RR, 2.03 (95% CI, 1.19-3.48). Rates of delayed bleeding RR, 0.42 (95% CI, 0.21-0.86) and perforation RR, 0.13 (95% CI, 0.03-0.59) were significantly lower with cold EMR. We found no significant difference in other outcomes between groups.
Conclusions:
Cold EMR is associated with lower risk of delayed bleeding and perforation but higher risk of recurrent or residual neoplasia compared with hot EMR.
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