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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Structural-functional connectivity decoupling in multiscale brain networks in Parkinson's disease.

Ting Zou1,2, Chen Chen3, Huafu Chen4,5

  • 1The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, P.R. China.

BMC Neuroscience
|December 26, 2024
PubMed
Summary

Parkinson's disease (PD) is linked to widespread structural-functional (SC-FC) decoupling in brain networks. This study reveals altered SC-FC coupling within and between brain networks in PD patients compared to healthy controls.

Keywords:
Multiscale brain networksParkinson’s diseaseStructural-functional coupling

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Network Science

Background:

  • Parkinson's disease (PD) involves neurodegeneration beyond the nigrostriatal pathway.
  • Structural-functional (SC-FC) coupling alterations in PD at the network level are understudied.
  • Subcortical regions' role in SC-FC coupling in PD requires further investigation.

Purpose of the Study:

  • To investigate changes in structural-functional (SC-FC) coupling in Parkinson's disease (PD).
  • To explore SC-FC coupling variations within and between functional brain networks.
  • To understand the network-level mechanisms underlying PD.

Main Methods:

  • Diffusion tensor imaging (DTI) for structural connectivity.
  • Resting-state functional magnetic resonance imaging (rs-fMRI) for functional connectivity.
  • Systematic construction and analysis of SC-FC coupling networks in 53 PD patients and 72 healthy controls (HCs).

Main Results:

  • Global reduction in SC-FC coupling observed in PD patients compared to HCs.
  • Regional SC-FC decoupling identified in the inferior parietal lobule, occipitotemporal cortex, motor cortex, and association cortex.
  • Intranetwork decoupling in visual, limbic, and association networks; internetwork decoupling involving visual, somatomotor, attention, and default mode networks. Increased subcortical-somatomotor coupling found in PD.

Conclusions:

  • PD is characterized by widespread SC-FC decoupling in brain network topology.
  • Findings provide insights into the brain network mechanisms implicated in Parkinson's disease.
  • Altered SC-FC coupling highlights network-level dysregulation in PD.