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Related Concept Videos

Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.

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Bioactive Deep Eutectic Solvent-Involved Sprayable Versatile Hydrogel for Monkeypox Virus Lesions Treatment.

Chen Chen1, Yu Chen2, Zhiyi Ye1

  • 1School of Chemical Engineering, Sichuan University, Chengdu 610065, P. R. China.

ACS Applied Materials & Interfaces
|December 27, 2024
PubMed
Summary
This summary is machine-generated.

A novel sprayable hydrogel containing rosmarinic acid-proanthocyanidin-glycol (RPG) was developed to treat monkeypox virus (MPXV) lesions. This advanced dressing offers UV-blocking, antibacterial, and antiviral properties for effective MPXV management.

Keywords:
MPXVbioactive deep eutectic solventpH-responsive releasesprayable hydrogelversatile functions

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Area of Science:

  • Biomaterials Science
  • Infectious Disease Therapeutics
  • Green Chemistry

Background:

  • Monkeypox virus (MPXV) infection presents challenges including secondary bacterial infections, skin pigmentation, and scarring.
  • Current treatments for MPXV lesions are often complex and may not adequately address diverse symptoms.

Purpose of the Study:

  • To develop a versatile, sprayable hydrogel for managing MPXV lesions.
  • To utilize a novel bioactive deep eutectic solvent (DES) for its therapeutic potential against MPXV.

Main Methods:

  • Synthesized a bioactive DES (rosmarinic acid-proanthocyanidin-glycol, RPG) and characterized its binding to MPXV proteins via molecular docking.
  • Formulated a sprayable hydrogel (PB-RPG-Xyl) incorporating RPG, poly(vinyl alcohol), borate, and xylitol.
  • Evaluated hydrogel properties including pH-responsive release, sprayability, self-healing, adhesion, shape-adaptability, degradability, biocompatibility, and functional activities (UV-blocking, antibacterial, antiviral).

Main Results:

  • Molecular docking indicated strong binding of RPG components to MPXV proteins.
  • The PB-RPG-Xyl hydrogel demonstrated pH-responsive RPG release, achieving 84.83% cumulative release at pH 5.5 within 210 min.
  • The hydrogel exhibited excellent sprayability, self-healing, adhesion, shape-adaptability, degradability, biocompatibility, and significant UV-blocking, antibacterial, and antiviral activities.

Conclusions:

  • The developed sprayable PB-RPG-Xyl hydrogel is the first natural bioactive DES-based dressing for MPXV lesions.
  • This innovation expands the application of green solvents in healthcare and offers a convenient, effective treatment for MPXV infections.
  • The hydrogel addresses complex treatment needs for difficult skin lesions associated with MPXV.