Composite Contrast Enhancement of Hydrogel-Based Implants for Photon-Counting Computed Tomography Studies
Evgeniya V Suslova1, Denis A Shashurin2, Konstantin I Maslakov1
1Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1 Bld. 3, 119991 Moscow, Russia.
Gels (Basel, Switzerland)
|December 27, 2024
Summary
This study enhances hydrogel implant visibility using lanthanide (Ln)-based contrast agents for photon-counting computed tomography (PCCT). This improves safety by making implants clearly detectable in medical imaging.
Area of Science:
- Biomaterials Science
- Medical Imaging
- Nanotechnology
Background:
- Hydrogels are widely used in medical implants.
- Limited visibility of hydrogels in conventional medical imaging poses safety risks.
- Photon-counting computed tomography (PCCT) offers potential for improved imaging.
Purpose of the Study:
- To enhance the visibility of hydrogel-based implants using lanthanide (Ln)-based contrast agents.
- To assess the feasibility of using Ln-based agents for hydrogel visualization in PCCT.
- To develop and evaluate novel Ln-based contrast agents for implant imaging.
Main Methods:
- Synthesized cross-linked nanosized Ln2O3 with polyacrylamide (PAM).
- Incorporated Ln-based contrast agents into gelatin and PAM hydrogels.
- Produced and evaluated prototype silicone implants with enhanced hydrogel fillings in phantom PCCT studies.
Main Results:
- Demonstrated contrast enhancement of hydrogels (gelatin, PAM) and silicone shells using Ln-based agents.
- Successfully produced cross-linked nanosized Ln2O3 with PAM via a novel synthetic route.
- Prototype implants showed improved detectability in PCCT phantom studies.
Conclusions:
- Lanthanide-based contrast agents can significantly enhance hydrogel implant visibility in PCCT.
- The developed Ln2O3-PAM nanocomposite is a promising contrast agent for medical implants.
- This approach improves the safety of implantable hydrogel systems through enhanced imaging.
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