Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Burn Injuries

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Authors' Response to "Vasopressors in Early Burn Resuscitation: Physiological Concerns Revisited".

Acta anaesthesiologica Scandinavica·2026

Same author

LIBRE GO!: A Mobile Application for Longitudinal Social Participation Assessment and Resources Connection after Burn Injury.

Journal of burn care & research : official publication of the American Burn Association·2026

Same author

Saturation Genome Editing reveals the functional impact of RAD51D <i>and</i> XRCC2 variants.

bioRxiv : the preprint server for biology·2026

Same author

Mental and Social Health Recovery after Major Burn Injuries: A Burn Model System Study.

Journal of burn care & research : official publication of the American Burn Association·2026

Same author

Development of Short Forms of the Preschool Life Impact Burn Recovery Evaluation 1 to 5 years.

Journal of burn care & research : official publication of the American Burn Association·2026

Same author

Teen Perspectives in Burn Recovery: Coproduction for a New Outcome Tool Measuring Interpersonal Relationships and Social Interactions.

Journal of burn care & research : official publication of the American Burn Association·2026

Search research articles

Related Experiment Video

Updated: May 8, 2025

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

Establishing a Collaborative Genomic Repository for Adult Burn Survivors: A Burn Model System Feasibility Study.

Stephen Sibbett¹, Jamie Oh¹, Gretchen Carrougher¹

¹Department of Surgery, University of Washington, Seattle, WA 98195, USA.

European Burn Journal

|December 27, 2024

Summary

This study established procedures for genetic data integration into a national burn database. While a pilot genetic analysis showed no significant findings due to sample size, the feasibility of multicenter genetic research was demonstrated.

Keywords:

genomics multicenter database precision medicine worrier/warrior gene

More Related Videos

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

Related Experiment Videos

Last Updated: May 8, 2025

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis

Published on: February 6, 2020

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

Area of Science:

Genetics
Burn Research
Bioinformatics

Background:

Longitudinal burn databases are crucial for understanding patient outcomes.
Integrating genetic data can offer deeper insights into burn recovery and resilience.
The catechol-O-methyltransferase (COMT) gene is linked to stress and resilience phenotypes.

Purpose of the Study:

To develop standard operating procedures for genetic sample handling and data integration.
To assess the feasibility of correlating genetic variations with functional outcomes in burn patients.
To explore participant motivations for genetic analysis in a burn cohort.

Main Methods:

Established protocols for genetic sample collection, storage, and DNA isolation.
Integrated genetic data with an existing national burn database.
Conducted a pilot study analyzing catechol-O-methyltransferase (COMT) gene variants in 111 participants.

Main Results:

Successfully developed and implemented standard operating procedures for genetic data integration.
No significant association was found between COMT variants and functional outcomes, likely due to insufficient sample size.
Thematic analysis revealed altruism and personal interest as primary reasons for consent, while privacy concerns dominated refusal.

Conclusions:

Standard operating procedures for genetic sample collection, storage, DNA isolation, and data integration were successfully developed.
The feasibility of multicenter collaborative research integrating genetic data into a national burn database was demonstrated.
Future research requires larger sample sizes to detect potential genetic associations with functional outcomes in burn survivors.