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Fermented Fish Collagen Diminished Photoaging-Related Collagen Decrease by Attenuating AGE-RAGE Binding Activity.

Seyeon Oh1, So Young Lee2, Jong-Won Jang1,3

  • 1Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea.

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|December 27, 2024
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Summary
This summary is machine-generated.

Fermented fish collagen (FC) combats skin photoaging by reducing advanced glycation end product (AGE)-receptor for AGE (RAGE) binding. This action decreases inflammation and improves skin elasticity and moisture.

Keywords:
AGE–RAGE binding activityadvanced glycation end productsfermented fish collagen

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Area of Science:

  • Dermatology
  • Biochemistry
  • Molecular Biology

Background:

  • Ultraviolet (UV) irradiation induces skin photoaging, characterized by wrinkles and reduced elasticity.
  • UV exposure increases advanced glycation end product (AGE)-receptor for AGE (RAGE) binding, leading to inflammation and NF-κB activation.
  • The AGE-RAGE pathway is a key mediator of UV-induced skin damage.

Purpose of the Study:

  • To investigate the potential of fermented fish collagen (FC) in mitigating skin photoaging.
  • To determine if FC can decrease AGE-RAGE binding activity and its downstream inflammatory signaling.
  • To evaluate FC's effects on collagen degradation and skin structural components.

Main Methods:

  • In vitro studies using UV-irradiated keratinocytes.
  • In vivo studies using UV-irradiated animal skin models.
  • Assays to measure AGE-RAGE binding, TNF-α secretion, NF-κB translocation, matrix metalloproteinase (MMP) expression, and collagen levels.

Main Results:

  • FC significantly reduced AGE-RAGE binding activity and TNF-α secretion in UV-irradiated keratinocytes.
  • FC inhibited NF-κB translocation and decreased MMP-1, MMP-3, and MMP-9 expression in UV-irradiated skin.
  • FC treatment led to increased Smad2/3, collagen fiber accumulation, skin moisture, and elasticity.

Conclusions:

  • Fermented fish collagen (FC) effectively attenuates skin photoaging induced by UV irradiation.
  • FC exerts its protective effects by downregulating the AGE-RAGE pathway and associated inflammatory signals.
  • FC promotes collagen synthesis and improves skin hydration and elasticity, offering a potential therapeutic agent for photoaging.