New Sesterterpenes from the Antarctic Sponge Suberites sp
Stine S H Olsen1, Sydney K Morrow1, Julia L Szabo1
1Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USA.
Marine Drugs
|December 27, 2024
Summary
Researchers discovered new compounds from an Antarctic sponge, with one showing moderate activity against respiratory syncytial virus (RSV). This finding offers potential for new antiviral therapies.
Area of Science:
- Marine natural products chemistry
- Antiviral drug discovery
- Organic chemistry
Background:
- Antarctic sponges, particularly *Suberites* sp., are a source of novel suberitane derivatives.
- Some previously identified suberitane derivatives exhibit bioactivity against respiratory syncytial virus (RSV).
Purpose of the Study:
- To isolate and characterize new chemical entities from Antarctic sponge *Suberites* sp.
- To evaluate the antiviral activity of isolated compounds against RSV.
Main Methods:
- NMR-guided isolation and purification techniques.
- High-resolution mass spectrometry (HR-MS) for molecular formula determination.
- X-ray diffraction (XRD) for definitive structural elucidation.
Main Results:
- Five new analogs (1-5), including suberitenone K (1), suberitandiol (2), abeosuberitandiol (3), furanosuberitandiol (4), and norsuberitenone B (5), were isolated.
- Compounds 3 and 4 possess unique structural features: ring contraction and a dihydrofuran ring, respectively.
- Suberitenone K (1) and previously reported suberitenone D (9) demonstrated moderate activity against RSV, with IC50 values of 39.8 μM and 15.0 μM.
Conclusions:
- The Antarctic sponge *Suberites* sp. continues to yield structurally diverse and biologically relevant compounds.
- New suberitane derivatives, particularly suberitenone K, show promise as potential agents for combating RSV infections.
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