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Solid phase extraction chromatography-based radiochemical isolation of cyclotron-produced 51Mn from enriched 54Fe
Kendall E Barrett1, Jason C Mixdorf1, Johan Svedjehed2
1University of Wisconsin Department of Medical Physics, 1111 Highland Avenue, Madison, WI 53705, United States of America.
None:
We report DGA extraction chromatography isolation of 51Mn from isotopically enriched 54Fe. The method has been studied in semi-automated and automated realizations. The former achieves a decay corrected radiochemical yield of 78 ± 1 % (n = 3) and a separation factor of (1.0 ± 0.8) x 105 (n = 3). With GE HealthCare's Solid Target Platform (STP) and FASTlab the latter, fully automated method achieves a decay corrected radiochemical yield of 87 ± 1 % (n = 3) and a separation factor of (2.7 ± 0.9) x 104 (n = 3). Both setups efficiently isolate cyclotron-produced 51MnCl2 suitable for human administration as determined by developed Chemistry, Manufacturing, and Controls (CMC) acceptance criteria, and support exploration of 51Mn as a clinical diagnostic tool.
