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Infectious intestinal diseases elevate neurodegenerative disease risk based on a nationwide population-based cohort
Fang-Chin Hsu1, Tzu-Hsuan Weng2, Ta-Wei Pu3
1Division of Colorectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Scientific Reports
|December 28, 2024
Summary
Infectious intestinal diseases (IIDs) significantly increase the risk of developing neurodegenerative diseases like Parkinson's. Managing IIDs may improve long-term neurological health outcomes.
Area of Science:
- Epidemiology
- Neuroscience
- Gastroenterology
Background:
- Infectious intestinal diseases (IIDs) represent a substantial global health and economic challenge.
- Emerging evidence suggests a potential link between IIDs and neurodegenerative diseases.
- Understanding this association is crucial for public health and patient management.
Purpose of the Study:
- To investigate the relationship between infectious intestinal diseases (IIDs) and the risk of developing neurodegenerative diseases.
- To quantify the association using a large-scale population-based cohort.
- To explore specific neurodegenerative conditions and the impact of IID frequency.
Main Methods:
- Population-based retrospective cohort study utilizing Taiwan's National Health Insurance Research Database (NHIRD).
- Inclusion of 297,438 patients (2000-2015), with 99,146 diagnosed with IIDs and a matched control group.
- Cox proportional regression analysis to assess hazard ratios (HRs) for neurodegenerative diseases, adjusting for covariates.
Main Results:
- Patients with IIDs exhibited a significantly higher overall risk of neurodegenerative diseases (aHR = 1.144, P < 0.001).
- Elevated risks were observed for Parkinson's disease, multiple sclerosis, and other neurodegeneration-associated disorders.
- A positive correlation was found between IID visit frequency and neurodegenerative disease risk.
Conclusions:
- This study provides robust evidence for a significant association between infectious intestinal diseases and increased neurodegenerative disease risk.
- Early detection and management of IIDs may play a role in mitigating long-term neurological health consequences.
- Further research is warranted to elucidate underlying mechanisms and inform targeted interventions.
