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Updated: May 8, 2025
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
ICAM-1 expression is upregulated in the umbilical vein endothelial cells in acute chorioamnionitis with foetal
B S Hanim1, Y P Wong1, G C Tan2
1Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Pathology, 56000 Kuala Lumpur, Malaysia.
Introduction:
ICAM-1 is an adhesion molecule expressed on the endothelial cells and is involved in regulating leukocyte recruitment to the site of inflammation. Elevated ICAM-1 mRNA expression was found in the serum of mothers with chorioamnionitis. This study aimed to determine the expression of ICAM-1 in the placenta and umbilical cord of pregnancy with chorioamnionitis, and its association with adverse neonatal outcome.
Materials And Methods:
This study comprised a total of 86 cases of which there were 35 cases of non-chorioamnionitis and 51 cases of chorioamnionitis consisting of acute subchorionitis/chorionitis (maternal inflammatory response (MIR) stage 1, n=17), acute chorioamnionitis (MIR stage 2, n=17) and acute necrotising chorioamnionitis (MIR stage 3, n=17). Formalin-fixed paraffin embedded placenta tissue blocks were retrieved from the histopathology archive. ICAM-1 immunohistochemistry was performed on all cases and their expressions were evaluated on cells of the umbilical vein, umbilical artery, foetal vessels and maternal vessels.
Results:
The expression of ICAM-1 in umbilical vein was significantly associated with cases of foetal inflammatory response (p<0.001).
Conclusion:
We found that ICAM-1 expression was upregulated in the endothelial cells of umbilical vein in acute chorioamnionitis with positive foetal inflammatory response. ICAM-1 might be involved in the pathogenesis of acute chorioamnionitis and funisitis. Further study using a larger cohort is needed to strengthen this observation.
