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Updated: May 12, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007
Xu-Meng Ren1,2, Ke-Yue Wu1,2, Shu-Hua Qi1
1CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Abstract:
Three new terpenoid derivatives (1S,6R,7S)-hydrobenzosydowic acid (1), (1 R,6S,7S)-hydrobenzosydowic acid (2), and (7 R,10R)-11-dehydroxy-iso-10-hydroxysydowic acid (3), along with the known analogues (S)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid (4) and trihydroxybutyl ester of 4-carboxydiorcinol (5) were isolated from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007. Their structures were determined by spectroscopic analysis. Compound 4 with a nitrobenzene group was isolated from nature for the first time. The antibacterial activities of 1-5 and cytotoxicity of 1-3 were also evaluated.
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