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Generating precision microbubbles for use as an echocardiographic contrast agent.

R S Meltzer, V Klig, L E Teichholz

    Journal of the American College of Cardiology
    |April 1, 1985
    PubMed
    Summary
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    Researchers developed a simple method to create precise microbubbles for quantitative echocardiography. These microbubbles are stable, controllable, and cost-effective for in vitro diagnostic imaging.

    Area of Science:

    • Biomedical Engineering
    • Medical Imaging
    • Materials Science

    Background:

    • Echocardiography requires effective contrast agents for quantitative analysis.
    • Existing microbubble agents may lack precision or be costly.

    Purpose of the Study:

    • To develop a simple method for generating precision microbubbles.
    • To evaluate their utility as a contrast agent for quantitative echocardiography.

    Main Methods:

    • Fabrication of microbubbles using a simple generator with a fluid pump and narrow bore tube.
    • Microbubble characterization using high-power microscopy.
    • In vitro testing with infusion into degassed water and ultrasonic imaging.
    • Quantitative analysis using videodensitometry.

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    Main Results:

    • Generation of up to 5,000 microbubbles/s with controllable radii (80-150 μm).
    • No significant interbubble size variation observed.
    • High correlation (r=0.71-0.89) between infusion rate and contrast effect.
    • Microbubbles demonstrated stability during experiments.

    Conclusions:

    • Precision microbubbles can be simply and cost-effectively generated on-site.
    • These microbubbles are suitable for quantitative echocardiographic studies in vitro.
    • The generated microbubbles exhibit sufficient stability for short-term storage.