Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From islet to blood: macrophage remodeling signatures for diagnosis and risk stratification in type 1 diabetes.

Frontiers in immunology·2026
Same author

Corrosion assessment in aluminum pipe based on nonlinear ultrasonic technique using macro fiber composite transducers.

PloS one·2026
Same author

Under the spotlight: social anxiety and music performance anxiety in solo-exposed wind instrumentalists compared to section players in orchestra settings.

Frontiers in psychology·2026
Same author

Enhanced Endocytosis and Mitochondrial Stress Underlie Severe Retinitis Pigmentosa With RHO P347L Mutant.

Investigative ophthalmology & visual science·2026
Same author

Serum integrative omics reveals predictive signatures for coronary artery disease.

Scientific reports·2026
Same author

The impact of emergency policy (contingency plans) on regional emergency logistics response capacity in China.

Frontiers in public health·2026

Related Experiment Video

Updated: May 7, 2025

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

908

Stimuli-responsive hydrogels for bone tissue engineering.

Congyang Xue1,2, Liping Chen1,3, Nan Wang1

  • 1Department of Orthopaedics, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.

Biomaterials Translational
|December 30, 2024
PubMed
Summary

Stimuli-responsive hydrogels show promise for bone tissue engineering by delivering therapeutic agents and forming scaffolds. However, challenges in biocompatibility and mechanical stability require further research for clinical use.

Keywords:
bone tissue engineeringdrug carrierhydrogelsstimuli-responsive

More Related Videos

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.8K
Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
08:50

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

6.7K

Related Experiment Videos

Last Updated: May 7, 2025

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

908
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.8K
Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
08:50

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

6.7K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Engineering

Background:

  • Bone defect treatment presents significant clinical challenges.
  • Bone tissue engineering offers solutions using biocompatible materials, cells, and bioactive factors.
  • Hydrogels are attractive due to their water content, degradability, and biocompatibility.

Purpose of the Study:

  • To review hydrogel sources, roles, and applications in bone tissue engineering.
  • To classify stimuli-responsive hydrogels based on response types.
  • To summarize the applications of these hydrogels in bone repair.

Main Methods:

  • Classification of hydrogels into physical, chemical, and biochemical response categories.
  • Review of existing literature on stimuli-responsive hydrogels for bone tissue engineering.
  • Analysis of hydrogel properties for drug/cell delivery and scaffold formation.

Main Results:

  • Stimuli-responsive hydrogels can form adhesive semi-solids for localized, controlled release of bone-enhancing factors, drugs, and cells.
  • These hydrogels can serve as scaffolds to promote bone defect repair.
  • Identified limitations include poor biocompatibility, immunogenicity, and mechanical instability.

Conclusions:

  • Stimuli-responsive hydrogels hold potential for bone tissue engineering applications.
  • Further research is essential to overcome current limitations and enable clinical translation.
  • Addressing biocompatibility and mechanical properties is crucial for future development.